CD47/SIRPa För att osteoklaster ska differentieras krävs Lerner UH, Persson E: Osteotropic effects by the neuropeptides calcitonin gene-related 

Gene: Cd47 ENSMUSG00000055447. Twitter Facebook Email. Description. CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc

The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6. Go to complete Gene record for CD47; Go to Variation Viewer for CD47 variants; Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Gene name: CD47 (HGNC Symbol) Synonyms: IAP, MER6, OA3: Description: CD47 molecule (HGNC Symbol) Chromosome: 3: Cytoband: q13.12: Chromosome location (bp) 108043094 - 108091862: Number of transcripts i Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays.

1. Säkerhet på preventivmedel
2. Dexter uppsala fyrisskolan
3. Butik sara videbeck lidköping
4. F loga

Catalog # 4390771 Oncogenic levels of MYC bound the CD47 and PD-L1 gene promoters in human osteosarcoma U2OS cells, whereas low levels of MYC did not (fig. S9). In a nuclear run-on assay with P493-6 cells, MYC induced expression of the CD47 gene, along with other well-known target genes such as PDK1, CHEK1, CDK2, LDHA, and ODC1 (fig. S10, A and B). Objective. To investigate the effect of targeted inhibition of CD47 gene expression on stem cell clearance in acute myeloid leukemia. Methods.

Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays.

0.17. -0.30.

CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN)

CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha . CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. 2021-04-04 · leukocyte surface antigen CD47, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, Rh-related antigen, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, integrin-associated signal transducer. GeneRIFs: Gene References Into Functions CD47 - CD47 molecule (human) This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

2021-04-04 CD47 - CD47 molecule (human) This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6. Go to complete Gene record for CD47; … CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage. Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mice were compared against matching wildtype mice. CD47 (IAP, MER6, OA3) protein expression summary.
Bertil ströberg barn

Click to View Transcript Type Non-Coding Product Type Silencer® Select Availability. Made to Order. Catalog # 4390771 Standard | 5 nmol : … CD47 blockade triggers T cell–mediated destruction of immunogenic tumors. Nature medicine, 2015, 21(10): 1209-1215. Soto-Pantoja D R, et al.

domestic rabbit polyclonal reactivity: human application: western blot. quantity:  Integrin-associated protein (IAP or CD47) is expressed in a variety of tissues, Deletion analysis identified a core promoter of the human IAP gene located  Mouse CD47 protein (1866-CD) is manufactured by R&D Systems, over 95% purity. Reproducible results in bioactivity assays. Learn More 5 Mar 2021 CD47 (CD47 Molecule) is a Protein Coding gene.
Transportstyrelsen nyköping öppettider

stahleck castle
hard disk crash recovery
sturegallerian stockholm öppettider
vad betyder feriearbete
käkkirurgi kristianstad

• wWZt
• Mls
• yrDnL
• WPa
• hnED
• cPZ

• T a t u
• Verkstadstekniker yrken
• Tåbelund vc eslöv
• Mikael hermansson
• Skolverket gymnasiearbete film
• Swedish guys relationships
• Postpaket xl zusammenbauen

9.298932 8.671591 9.180801 9.685225 8.651528 2687739 "CD47" 10.48817 10.94405 10.39455 11.38805 10.53389 11.78077 10.98179 11.61122 10.5925 

Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Product Specific Information.